RIN3 Rabbit Polyclonal Antibody

Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016], caution:The region from Asp-168 to Pro-327 is deduced from the genomic sequence by similarity to the mouse sequence., function:Potential Ras effector protein. May function as a guanine nucleotide exchange (GEF), by exchanging bound GDP for free GTP., similarity:Belongs to the RIN (Ras interaction/interference) family., similarity:Contains 1 Ras-associating domain., similarity:Contains 1 SH2 domain., similarity:Contains 1 VPS9 domain., subcellular location:Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles., subunit:Interacts with RAB5B and BIN1., tissue specificity:Widely expressed.