RGS16 (phospho Tyr168) Rabbit Polyclonal Antibody

The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008], function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G (i) -alpha and G (o) -alpha, but not to G (s) -alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade., PTM:Palmitoylated on Cys-2 and/or Cys-12., PTM:Phosphorylation on Tyr-168 upon EGFR stimulation. Enhanced GTPase accelerating (GAP) activity on G (i) -alpha., similarity:Contains 1 RGS domain., tissue specificity:Abundantly expressed in retina with lower levels of expression in most other tissues.

RGS16; RGSR; Regulator of G-protein signaling 16; RGS16; A28-RGS14P; Retinal-specific RGS; RGS-r; hRGS-r; Retinally abundant regulator of G-protein signaling