RhoGEF p115 Rabbit Polyclonal Antibody

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008], domain:The DH domain is involved in interaction with CCPG1., domain:The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity., function:Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12., PTM:Phosphorylated by PKCA., sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part., similarity:Contains 1 DH (DBL-homology) domain., similarity:Contains 1 PH domain., similarity:Contains 1 RGSL (RGS-like) domain., subcellular location:Translocated to the membrane by activated GNA13 or LPA stimulation., subunit:Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1 (By similarity) . Interacts with CTNNAL1., tissue specificity:Ubiquitously expressed.