PIG-X Rabbit Polyclonal Antibody

This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER) . The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009], function:Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM., pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis., PTM:N-glycosylated., sequence caution:Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon., similarity:Belongs to the PIGX family., subunit:Interacts with PIGM.