MTERF Rabbit Polyclonal Antibody

This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008], domain:Composed of three leucine zippers, one of which is bipartite, and two widely spaced basic domains. There is evidence that the leucine zippers form and intramolecular three-stranded coiled-coil that brings the basic domains together to form a DNA-binding motif., function:Transcription termination factor. Binds to a 28 bp region within the tRNA (Leu (uur) ) gene at a position immediately adjacent to and downstream of the 16S rRNA gene, this region comprises a tridecamer sequence critical for directing accurate termination. Probably requires one or more components for termination activity., PTM:Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation., similarity:Belongs to the mTERF family., subunit:Monomer.