LPD lipase Rabbit Polyclonal Antibody

The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014], disease:Defects in LIPI may be a cause of susceptibility to familial hypertrigliceridemia [MIM:145750]. Familial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis., enzyme regulation:Inhibited by sodium vanadate., function:Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA) ., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the AB hydrolase superfamily. Lipase family., subcellular location:May associate with lipid draft., subunit:Interacts with heparin with a high affinity., tissue specificity:Expressed in testis. Expressed exclusively at the connecting piece of the sperm.

LIPI; LPDL; PRED5; Lipase member I; LIPI; Cancer/testis antigen 17; CT17; LPD lipase; Membrane-associated phosphatidic acid-selective phospholipase A1-beta; mPA-PLA1 beta