Involucrin Rabbit Polyclonal Antibody

Involucrin (IVL) Homo sapiens Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008], function:Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia., PTM:Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide., similarity:Belongs to the involucrin family., subcellular location:Constituent of the scaffolding of the cornified envelope., subunit:Directly or indirectly cross-linked to cornifelin (CNFN) ., tissue specificity:Keratinocytes of epidermis and other stratified squamous epithelia.