Granzyme H Rabbit Polyclonal Antibody

This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015], function:This enzyme is probably necessary for target cell lysis in cell-mediated immune responses., similarity:Belongs to the peptidase S1 family., similarity:Belongs to the peptidase S1 family. Granzyme subfamily., similarity:Contains 1 peptidase S1 domain., subcellular location:Cytoplasmic granules of cytolytic T-lymphocytes.