DNA Ligase I Rabbit Polyclonal Antibody

This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014], catalytic activity:ATP + (deoxyribonucleotide) (n) + (deoxyribonucleotide) (m) = AMP + diphosphate + (deoxyribonucleotide) (n+m) ., cofactor:Magnesium., disease:Defects in LIG1 seem to cause immunodeficiencies and cellular hypersensitivity to DNA-damaging agents., function:DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair., online information:DNA ligase entry, online information:LIG1 mutation db, similarity:Belongs to the ATP-dependent DNA ligase family.