DNA Ligase I Rabbit Polyclonal Antibody
Product Specifications
Background
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014], catalytic activity:ATP + (deoxyribonucleotide) (n) + (deoxyribonucleotide) (m) = AMP + diphosphate + (deoxyribonucleotide) (n+m) ., cofactor:Magnesium., disease:Defects in LIG1 seem to cause immunodeficiencies and cellular hypersensitivity to DNA-damaging agents., function:DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair., online information:DNA ligase entry, online information:LIG1 mutation db, similarity:Belongs to the ATP-dependent DNA ligase family.
Product Name Alternative
LIG1; DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1
Gene Name
LIG1
Gene ID
3978
Swiss Prot
P18858
Host
Rabbit
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
DNA replication; Base excision repair; Nucleotide excision repair; Mismatch repair
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:10000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
133kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
