SB-772077B (dihydrochloride)
Product Specifications
UNSPSC Description
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase (ROCK) inhibitor with IC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively[1].
Target Antigen
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sb-772077b-dihydrochloride.html
Purity
99.0
Solubility
DMSO : 38.33 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 100 mg/mL (ultrasonic)
Smiles
[H]Cl.O=C(C1=CN=CC2=C1N(CC)C(C3=NON=C3N)=N2)N4C[C@@H](N)CC4.[H]Cl
Molecular Weight
415.28
References & Citations
[1]Doe C, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-108518/SB-772077B-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-108518/SB-772077B-dihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
607373-46-6
Available Sizes
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