SB-772077B (dihydrochloride)
SB-772077B dihydrochloride is an orally active aminofuran-based Rho kinase ((ROCK) ) inhibitor with IC50 values of 5.6 nM and 6 nM for ROCK1 and ROCK2, respectively. SB-772077B dihydrochloride reduces inflammatory cytokines (TNF-α and IL-6) . SB-772077B dihydrochloride relaxes aortic rings and lowers blood pressure. SB-772077B dihydrochloride can be used in the research of inflammatory diseases[1][2].
Product Specifications
CAS Number
[607373-46-6]
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sb-772077b-dihydrochloride.html
Purity
99.33
Solubility
DMSO : 38.33 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 100 mg/mL (ultrasonic)
Smiles
[H]Cl.O=C(C1=CN=CC2=C1N(CC)C(C3=NON=C3N)=N2)N4C[C@@H](N)CC4.[H]Cl
Molecular Formula
C15H20Cl2N8O2
Molecular Weight
415.28
References & Citations
[1]Doe C, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320 (1) :89-98.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK1; ROCK2
Available Sizes
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