DHRS4 Rabbit Polyclonal Antibody

Catalytic activity:R-CHOH-R' + NADP (+) = R-CO-R' + NADPH., function:Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones., miscellaneous:Inhibited by kaempferol, quercetin, genistein and myristic acid., similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family., subcellular location:Isoform 1 is peroxisomal, while isoform 4 is not., subunit:Homotetramer., tissue specificity:Isoform 1 is predominantly expressed in normal cervix (at protein level) . Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level) . Isoforms 5 and 6 are expressed in a few neoplastic cervical tissues., catalytic activity:R-CHOH-R' + NADP (+) = R-CO-R' + NADPH., function:Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones., miscellaneous:Inhibited by kaempferol, quercetin, genistein and myristic acid., similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family., subcellular location:Isoform 1 is peroxisomal, while isoform 4 is not., subunit:Homotetramer., tissue specificity:Isoform 1 is predominantly expressed in normal cervix (at protein level) . Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level) . Isoforms 5 and 6 are expressed in a few neoplastic cervical tissues.

DHRS4; Dehydrogenase/reductase SDR family member 4; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; CR; PHCR; NADPH-dependent retinol dehydrogenase/reductase; NRDR; humNRDR; Peroxisomal short-chain alcohol dehydrogenase; PSCD