DGK-α Rabbit Polyclonal Antibody

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008], catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate., enzyme regulation:Stimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C., function:Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity., similarity:Belongs to the eukaryotic diacylglycerol kinase family., similarity:Contains 1 DAGKc domain., similarity:Contains 2 EF-hand domains., similarity:Contains 2 phorbol-ester/DAG-type zinc fingers., subunit:Monomer., tissue specificity:Lymphocytes and oligodendroglial cells.