Carbonyl Reductase 1 Rabbit Polyclonal Antibody

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013], catalytic activity: (13E) - (15S) -11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP (+) = (13E) -11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH., catalytic activity: (5Z,13E) - (15S) -9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP (+) = (5Z,13E) - (15S) -11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH., catalytic activity:R-CHOH-R' + NADP (+) = R-CO-R' + NADPH., function:Catalyzes the reduction of a wide variety of carbonyl compounds including the antitumor anthracycline antibiotics. Can convert prostaglandin E2 to prostaglandin F2-alpha., similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family., subunit:Monomer.

CBR1; CBR; CRN; Carbonyl reductase [NADPH] 1; 15-hydroxyprostaglandin dehydrogenase [NADP (+) ]; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E (2) 9-reductase