A Cyclase IX Rabbit Polyclonal Antibody

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008], catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate., cofactor:Binds 2 magnesium ions per subunit., enzyme regulation:Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation., function:May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin., similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family., similarity:Contains 2 guanylate cyclase domains., tissue specificity:Expressed in multiple cells of the lung, with expression highest in airway smooth muscle.

Purine metabolism; Calcium; Chemokine; Oocyte meiosis; Vascular smooth muscle contraction; Gap junction; GnRH; Progesterone-mediated oocyte maturation; Melanogenesis; Vibrio cholerae infection; Dilated cardiomyopathy