PENK Rabbit Polyclonal Antibody

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015], function:Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK (114-133) and PENK (237-258) increase glutamate release in the striatum. PENK (114-133) decreases GABA concentration in the striatum., PTM:The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing., similarity:Belongs to the opioid neuropeptide precursor family.