LTB4DH Rabbit Polyclonal Antibody

This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009], catalytic activity:11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD (P) (+) = (5Z) - (13E) -11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD (P) H., catalytic activity:n-alkanal + NAD (P) (+) = alk-2-enal + NAD (P) H., function:Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity) . Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4., similarity:Belongs to the NADP-dependent oxidoreductase L4BD family., subunit:Monomer or homodimer., tissue specificity:High expression in the kidney, liver, and intestine but not in leukocytes.