C9 Rabbit Polyclonal Antibody

This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC) . The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009], disease:Defects in C9 are a cause of component C9 deficiency (C9D) [MIM:120940]. Patients with C9D suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis., function:C9 is the final component of the complement system to be added in the assembly of the membrane attack complex. It is able to enter lipid bilayers, forming transmembrane channels., online information:C9 mutation db, PTM:Thrombin cleaves factor C9 to produce C9a and C9b., similarity:Belongs to the complement C6/C7/C8/C9 family., similarity:Contains 1 EGF-like domain., similarity:Contains 1 LDL-receptor class A domain., similarity:Contains 1 MACPF domain., similarity:Contains 1 TSP type-1 domain.