BMP-3A Rabbit Polyclonal Antibody

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016], function:Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification., induction:Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts., online information:Bone morphogenetic protein 3 entry, similarity:Belongs to the TGF-beta family., subunit:Homodimer; disulfide-linked., tissue specificity:Expressed in adult and fetal cartilage.