Ataxin-2L Rabbit Polyclonal Antibody

This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], PTM:Arg-361 is dimethylated, probably to asymmetric dimethylarginine., PTM:Thrombopoietin triggers the phosphorylation on tyrosine residues in a way that is dependent on MPL C-terminal domain., sequence caution:Exon duplication., similarity:Belongs to the ataxin-2 family., subunit:Interacts with MPL/TPOR and EPOR and dissociates after ligand stimulation., tissue specificity:Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.