Granzyme M Rabbit Polyclonal Antibody

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012], function:Cleaves peptide substrates after methionine, leucine, and norleucine., similarity:Belongs to the peptidase S1 family. Granzyme subfamily., similarity:Contains 1 peptidase S1 domain., subcellular location:Granules of large granular lymphocytes.