ATP-citrate synthase (phospho Ser455) Rabbit Polyclonal Antibody

ATP citrate lyase (ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014], catalytic activity:ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA., function:ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine., similarity:In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family., similarity:In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family., subunit:Homotetramer.