Moesin/Ezrin/Radixin (phospho Thr558) Rabbit Polyclonal Antibody

Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008], function:Probably involved in connections of major cytoskeletal structures to the plasma membrane., PTM:Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures., similarity:Contains 1 FERM domain., subcellular location:Phosphorylated form is enriched in microvilli-like structures at apical membrane., subunit:In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity) . Binds SLC9A3R1., tissue specificity:In all tissues and cultured cells studied.