Moesin/Ezrin/Radixin (phospho Thr558) Rabbit Polyclonal Antibody
Product Specifications
Background
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008], function:Probably involved in connections of major cytoskeletal structures to the plasma membrane., PTM:Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures., similarity:Contains 1 FERM domain., subcellular location:Phosphorylated form is enriched in microvilli-like structures at apical membrane., subunit:In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity) . Binds SLC9A3R1., tissue specificity:In all tissues and cultured cells studied.
Product Name Alternative
MSN; Moesin; Membrane-organizing extension spike protein; RDX; Radixin; EZR; VIL2; Ezrin; Cytovillin; Villin-2; p81
Gene Name
MSN
Gene ID
4478/5962
Swiss Prot
P26038/P35241/P15311
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
Leukocyte transendothelial migration; Regulates Actin and Cytoskeleton
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:200-1:1000, ELISA 1:5000-1:10000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Phosphorylated
Molecular Weight
67kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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