PDGFR-β (phospho Tyr751) Rabbit Polyclonal Antibody

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008], catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., disease:A chromosomal aberration involving PDGFRB is a cause in many instances of chronic myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t (5;12) with ETV6 on chromosome 12 creating an PDGFRB-ETV6 fusion protein., disease:A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic leukemia (CMML) . Translocation t (5;12) (q33; p13) with EVT6/TEL. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML) ., disease:A chromosomal aberration involving PDGFRB may be a cause of acute myelogenous leukemia. Translocation t (5;14) (q33; q32) with TRIP11. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia., disease:A chromosomal aberration involving PDGFRB may be a cause of juvenile myelomonocytic leukemia. Translocation t (5;17) (q33; p11.2) with SPECC1., disease:A chromosomal aberration involving PDGFRB may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t (1;5) (q23; q33) that forms a PDE4DIP-PDGFRB fusion protein., function:Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains., subunit:Homodimer, and heterodimer with PDGFRA. Interacts with APS. The autophosphorylated form interacts directly with SHB and with PIK3C2B, maybe indirectly.

PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-deri

MAPK_ERK_Growth; MAPK_G_Protein; Calcium; Cytokine-cytokine receptor interaction; Focal adhesion; Gap junction; Regulates Actin and Cytoskeleton; Pathways in cancer; Colorectal cancer; Glioma; Prostate cancer; Melanoma