CaMKIV Rabbit Polyclonal Antibody

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca (2+) /calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008], catalytic activity:ATP + a protein = ADP + a phosphoprotein., enzyme regulation:Activated by Ca (2+) /calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2. Autophosphorylation of the N-terminus is required for full activation. In part, activity is independent on Ca (2+) /calmodulin and autophosphorylation of Ser-336 allows to switch to a Ca (2+) /calmodulin-independent state (By similarity) . Probably inactivated by serine/threonine protein phosphatase 2A., function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory., PTM:Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity) . Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily., similarity:Contains 1 protein kinase domain., subcellular location:Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix., subunit:Monomer (By similarity) . Interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca (2+) /calmodulin., tissue specificity:Expressed in epithelial ovarian cancer tissue.