HSL (phospho Ser552) Rabbit Polyclonal Antibody

The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008], catalytic activity:Diacylglycerol + H (2) O = monoacylglycerol + a carboxylate., catalytic activity:Monoacylglycerol + H (2) O = glycerol + a carboxylate., catalytic activity:Triacylglycerol + H (2) O = diacylglycerol + a carboxylate., enzyme regulation:Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin., function:In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production., pathway:Glycerolipid metabolism; triacylglycerol degradation., similarity:Belongs to the 'GDXG' lipolytic enzyme family., subcellular location:Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation., subunit:Interacts with PTRF in the adipocyte cytoplasm.