Cyclin B1 (phospho Ser147) Rabbit Polyclonal Antibody

The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34 (cdc2) to form the maturation-promoting factor (MPF) . Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008], developmental stage:Accumulates steadily during G2 and is abruptly destroyed at mitosis., function:Essential for the control of the cell cycle at the G2/M (mitosis) transition., PTM:Ubiquitinated by the SCF (NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases., similarity:Belongs to the cyclin family., similarity:Belongs to the cyclin family. Cyclin AB subfamily., subunit:Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF) . The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase.