CtBP1 (phospho Ser422) Rabbit Polyclonal Antibody

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008], cofactor:NAD. Required for efficient interaction with E1A. Cofactor binding induces a conformation change., function:Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity) . Co-repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity., PTM:ADP-ribosylated; when cells are exposed to brefeldin-A (BFA) ., PTM:Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4., PTM:The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation., similarity:Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family., subunit:Interacts with the C-terminus of adenovirus E1A protein, ELK3 and CTIP via their consensus motif P-X-[DNS]-L-[STVA]. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with FOXP2, HDAC4, HDAC5 and HDAC9. Interacts with GLIS2 but not GLIS1 or GLIS3 (By similarity) . Interacts with FOXP1, HIPK2, PNN and NRIP1. Interacts with ZFHX1B and WIZ. Interacts with Epstein-Barr virus EBNA3 and EBNA6.