NOS3 (phospho Thr494) Rabbit Polyclonal Antibody

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009], catalytic activity:L-arginine + n NADPH + n H (+) + m O (2) = citrulline + nitric oxide + n NADP (+) ., cofactor:Binds 1 FAD., cofactor:Binds 1 FMN., cofactor:Heme group., cofactor:Tetrahydrobiopterin (BH4) . May stabilize the dimeric form of the enzyme., enzyme regulation:Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN., function:Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF) -induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets., online information:Nitric oxide synthase entry, polymorphism:Variation in NOS3 seem to be associated with susceptibility to coronary spasm., similarity:Belongs to the NOS family., similarity:Contains 1 FAD-binding FR-type domain., similarity:Contains 1 flavodoxin-like domain., subcellular location:Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity., subunit:Homodimer. Interacts with NOSIP and NOSTRIN., tissue specificity:Platelets, placenta, liver and kidney.