Bcl-6 (phospho Ser333) Rabbit Polyclonal Antibody

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015], disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27; q23) with POU2AF1/OBF1., disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t (3;4) (q27; p11) with ARHH/TTF., disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t (3;14) (q27; q32) ; translocation t (3;22) (q27; q11) with immunoglobulin gene regions., function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis., induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan., PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway., similarity:Contains 1 BTB (POZ) domain., similarity:Contains 6 C2H2-type zinc fingers., subunit:Interacts with ZBTB7 and BCL6B (By similarity) . Interacts with the catalytic domain of HDAC9., tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.

BCL6; BCL5; LAZ3; ZBTB27; ZNF51; B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51