SAE1 Rabbit Polyclonal Antibody

SUMO1 activating enzyme subunit 1 (SAE1) Homo sapiens Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]) .[supplied by OMIM, Mar 2010], function:The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2., pathway:Protein modification; protein sumoylation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the ubiquitin-activating E1 family., subunit:Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2., tissue specificity:Expression level increases during S phase and drops in G2 phase (at protein level) .