PHyde Rabbit Polyclonal Antibody

STEAP3 metalloreductase (STEAP3) Homo sapiens This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015], caution:Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is probably not the case (PubMed:12866033) ., cofactor:FAD., function:Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe (3+) to Fe (2+) . Can also reduce of Cu (2+) to Cu (1+), suggesting that it participates in copper homeostasis. Uses NAD (+) as acceptor (By similarity) . May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP., induction:By p53/TP53., similarity:Belongs to the STEAP family., similarity:Contains 1 ferric oxidoreductase domain., subcellular location:Localizes to vesicular-like structures at the plasma membrane and around the nucleus., subunit:Interacts with BNIP3L, MYT1 and TCTP., tissue specificity:Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.

STEAP3; TSAP6; Metalloreductase STEAP3; Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHyde