PFK-B Rabbit Polyclonal Antibody

This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis) . This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014], catalytic activity:ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate., cofactor:Magnesium., enzyme regulation:Allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate., miscellaneous:In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes., pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4., similarity:Belongs to the phosphofructokinase family. Two domains subfamily., subunit:Tetramer. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3.