PFK-2 liv Rabbit Polyclonal Antibody

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012], catalytic activity:ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate., catalytic activity:Beta-D-fructose 2,6-bisphosphate + H (2) O = D-fructose 6-phosphate + phosphate., enzyme regulation:Phosphorylation results in inhibition of the kinase activity., function:Synthesis and degradation of fructose 2,6-bisphosphate., similarity:In the C-terminal section; belongs to the phosphoglycerate mutase family., subunit:Homodimer., tissue specificity:Liver.

PFKFB1; F6PK; PFRX; 6-phosphofructo-2-kinase/fructose-2; 6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; PFK/FBPase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme