MIPP Rabbit Polyclonal Antibody

This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009], catalytic activity:Myo-inositol hexakisphosphate + H (2) O = myo-inositol pentakisphosphate (mixed isomers) + phosphate., disease:Defects in MINPP1 may be involved in follicular thyroid tumors development., function:Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (By similarity) . May play a role in bone development (endochondral ossification) ., tissue specificity:Widely expressed with highest levels in kidney, liver and placenta.

MINPP1; MIPP; Multiple inositol polyphosphate phosphatase 1; 2; 3-bisphosphoglycerate 3-phosphatase; 2,3-BPG phosphatase; Inositol; 1,3,4,5) -tetrakisphosphate 3-phosphatase; Ins (1,3,4,5) P (4) 3-phosphatase