MAGI-2 Rabbit Polyclonal Antibody

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008], function:Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation., similarity:Belongs to the MAGUK family., similarity:Contains 1 guanylate kinase-like domain., similarity:Contains 2 WW domains., similarity:Contains 6 PDZ (DHR) domains., subcellular location:Membrane-associated in synaptosomes., subunit:Interacts via its WW domains with DRPLA. Interacts via its second PDZ domain with PTEN unphosphorylated C-terminus; this interaction diminishes the degradation rate of PTEN (By similarity) . Interacts through its guanylate kinase domain with DLGAP1 (By similarity) . Interacts through the PDZ domains with GRIN2A, GRID2 and NLGN1 (By similarity) . Interacts with CTNND2, CTNNB1, MAGUIN-1, ACVR2A, SMAD2 and SMAD3 (By similarity) . Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity) . May interact with HTR2A (By similarity) . Interacts with IGSF9, RAPGEF2 and HTR4 (By similarity) . Interacts with DDN., tissue specificity:Specifically expressed in brain.

MAGI2; ACVRINP1; AIP1; KIAA0705; Membrane-associated guanylate kinase; WW and PDZ domain-containing protein 2; Atrophin-1-interacting protein 1; AIP-1; Atrophin-1-interacting protein A; Membrane-associated guanylate kinase inverted 2; MAGI-