Integrin α2 Rabbit Polyclonal Antibody

Integrin subunit alpha 2 (ITGA2) Homo sapiens This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012], domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage., function:Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix., polymorphism:Position 534 is associated with platelet-specific alloantigen HPA-5 (Br) . HPA-5A/Br (a) has Lys-534 and HPA-5B/Br (b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP) . The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD) ., similarity:Belongs to the integrin alpha chain family., similarity:Contains 1 VWFA domain., similarity:Contains 7 FG-GAP repeats., subunit:Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor.

ITGA2; CD49B; Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD49b

Focal adhesion; ECM-receptor interaction; Hematopoietic cell lineage; Regulates Actin and Cytoskeleton; Pathways in cancer; Small cell lung cancer; Hypertrophic cardiomyopathy (HCM) ; Arrhythmogenic right ventricular cardiomyopathy (ARVC) ; Dilated cardiomyopathy