IDH3A Rabbit Polyclonal Antibody

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP (+) -dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD (+) -dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD (+) -dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008], catalytic activity:Isocitrate + NAD (+) = 2-oxoglutarate + CO (2) + NADH., cofactor:Binds 1 magnesium or manganese ion per subunit., similarity:Belongs to the isocitrate and isopropylmalate dehydrogenases family., subunit:Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.