GCS-β-1 Rabbit Polyclonal Antibody

This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate) . The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014], catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate., cofactor:Binds 1 or 2 heme groups per heterodimer., enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions., miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms., similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family., similarity:Contains 1 guanylate cyclase domain., subunit:Heterodimer of an alpha and a beta chain.

GUCY1B3; GUC1B3; GUCSB3; GUCY1B1; Guanylate cyclase soluble subunit beta-1; GCS-beta-1; Guanylate cyclase soluble subunit beta-3; GCS-beta-3; Soluble guanylate cyclase small subunit