CLIP3 Rabbit Polyclonal Antibody

This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010], domain:Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD) ., function:Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics., miscellaneous:The N-terminal half is dispensable for proper Golgi targeting, whereas the GoLD region is required., similarity:Contains 2 CAP-Gly domains., similarity:Contains 3 ANK repeats., subcellular location:Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae., subunit:Homodimer.

CLIP3; CLIPR59; CAP-Gly domain-containing linker protein 3; Cytoplasmic linker protein 170-related 59 kDa protein; CLIP-170-related 59 kDa protein; CLIPR-59