AQP0 Rabbit Polyclonal Antibody
Product Specifications
Background
Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008], disease:Defects in MIP are a cause of autosomal recessive congenital cataract [MIM:154050]., domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA) ., function:Water channel. May be responsible for regulating the osmolarity of the lens., similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family., tissue specificity:Major component of lens fiber gap junctions.
Product Name Alternative
MIP; AQP0; Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26
Gene Name
MIP
Gene ID
4284
Swiss Prot
P30301
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:5000-1:10000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
28kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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