ACTR-IB Rabbit Polyclonal Antibody

This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010], catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate., cofactor:Magnesium or manganese., function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TTRAP., PTM:Autophosphorylated., similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily., similarity:Contains 1 GS domain., similarity:Contains 1 protein kinase domain., subunit:Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. Interacts with TTRAP., tissue specificity:Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.

ACVR1B; ACVRLK4; ALK4; Activin receptor type-1B; Activin receptor type IB; ACTR-IB; Activin receptor-like kinase 4; ALK-4; Serine/threonine-protein kinase receptor R2; SKR2

MAPK_ERK_Growth; MAPK_G_Protein; Cytokine-cytokine receptor interaction; Endocytosis; TGF-beta; Adherens_Junction; Pathways in cancer; Colorectal cancer; Pancreatic cancer; Chronic myeloid leukemia