14-3-3 η Rabbit Polyclonal Antibody

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009], function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner., similarity:Belongs to the 14-3-3 family., subunit:Homodimer (By similarity) . Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form) ; the interaction retains it in the cytoplasm. Interacts with RGNEF and PCTK1 (By similarity) . Weakly interacts with CDKN1B., tissue specificity:Expressed mainly in the brain and present in other tissues albeit at lower levels.