RGS12 Rabbit Polyclonal Antibody

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase) -activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008], function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 GoLoco domain., similarity:Contains 1 PDZ (DHR) domain., similarity:Contains 1 PID domain., similarity:Contains 1 RGS domain., similarity:Contains 2 RBD (Ras-binding) domains., tissue specificity:Isoform 3 is brain specific.