HSC 70 Rabbit Polyclonal Antibody

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011], function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones., induction:Constitutively synthesized., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the heat shock protein 70 family., subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV., subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity) . Interacts with PACRG and TSC2. Interacts with SV40 VP1., tissue specificity:Ubiquitous.