Fyb Rabbit Polyclonal Antibody

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011], function:Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2) . Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2., PTM:T-cell receptor ligation leads to increased tyrosine phosphorylation., similarity:Contains 1 SH3 domain., subunit:Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity) . Interacts with FYN, LCP2, SKAP1 and SKAP2., tissue specificity:Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.

FYB; SLAP130; FYN-binding protein; Adhesion and degranulation promoting adaptor protein; ADAP; FYB-120/130; p120/p130; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein