GCS-α-1 Rabbit Polyclonal Antibody
Product Specifications
Background
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012], catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate., enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions., miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms., similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family., similarity:Contains 1 guanylate cyclase domain., subunit:Heterodimer of an alpha and a beta chain.
Product Name Alternative
GUCY1A3; GUC1A3; GUCSA3; GUCY1A1; Guanylate cyclase soluble subunit alpha-3; GCS-alpha-3; GCS-alpha-1; Soluble guanylate cyclase large subunit
Gene Name
GUCY1A3
Gene ID
2982
Swiss Prot
Q02108
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
Purine metabolism; Vascular smooth muscle contraction; Gap junction; Long-term depression
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:20000-1:40000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
77kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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