GCS-α-1 Rabbit Polyclonal Antibody

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012], catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate., enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions., miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms., similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family., similarity:Contains 1 guanylate cyclase domain., subunit:Heterodimer of an alpha and a beta chain.