CTGF Rabbit Polyclonal Antibody

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009], function:Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis., similarity:Belongs to the CCN family., similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain., similarity:Contains 1 IGFBP N-terminal domain., similarity:Contains 1 TSP type-1 domain., similarity:Contains 1 VWFC domain., subunit:Monomer.

Connective tissue growth factor (CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8)